|
Mammary Neoplasms
|
0.330 |
GeneticVariation
|
group |
LHGDN |
Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy.
|
16317586 |
2006 |
|
Mammary Neoplasms
|
0.330 |
GeneticVariation
|
group |
LHGDN |
Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women.
|
15093672 |
2004 |
|
Mammary Neoplasms
|
0.330 |
GeneticVariation
|
group |
LHGDN |
Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy.
|
12419790 |
2002 |
|
Mammary Neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy.
|
30120701 |
2018 |
|
Prostatic Neoplasms
|
0.310 |
GeneticVariation
|
group |
LHGDN |
Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population.
|
18368507 |
2008 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians.
|
14973106 |
2004 |
|
Autosome Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes.
|
16537716 |
2006 |
|
Chromosome Aberrations
|
0.300 |
Biomarker
|
group |
CTD_human |
A statistically significant effect was seen for SULT1A2 genotype on a 24DNT Hb-adduct; GSTP1 genotype on a 2,4,6-trinitrotoluene Hb-adduct; and SULT1A1, SULT1A2, NAT1, GSTT1, and GSTP1 genotypes on chromosomal aberrations in the exposed workers.
|
16537716 |
2006 |
|
Colonic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
15059925 |
2004 |
|
Urologic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma.
|
18006944 |
2007 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk.
|
18854828 |
2008 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphism of sulfotransferase 1A1, cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population.
|
19120511 |
2008 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cytotoxicity of PST-PTX nanoparticles in cancer cell lines and resistant cancer cell lines were determined by MTT assay.
|
31201909 |
2019 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, studies on the association between SULT1A1 Arg213His polymorphism and cancer susceptibility are inconsistent.
|
21670965 |
2012 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
SULT1A1 genotypes were successfully detected using the PCR-RFLP assay in 60 primary brain tumor patients and 156 hospital-based healthy control individuals with no history of cancer or precancerous disorder.
|
17605044 |
2008 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A positive correlation of C allele of CYP1A2*1F and G allele of SULT1A1*2 with hormone-dependent cancers in women was found.
|
16402077 |
2006 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although the number of samples was relatively small, our results suggest that DNA methylation in the SULT1A1 gene appears to be present in breast tissue including cancer and methylation significantly impacts transcriptional silencing of the gene.
|
16328031 |
2006 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Overall, we found SULT1A1 Arg213His polymorphism can increase cancer risk under heterozygous (OR 1.09, 95% CI = 1.01-1.18, P = 0.040), dominant (OR = 1.10, 95% CI = 1.01-1.19, P = 0.021) and allelic (OR = 1.08, 95% CI = 1.02-1.16, P = 0.015) models.
|
25225888 |
2014 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer.
|
18006944 |
2007 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings highlight the key insights of structural consequences caused by R213H mutation, which would enrich the understanding regarding the role of SULT1A1 mutation in cancer development and also xenobiotics management to individuals in the different treatment stages.
|
31835852 |
2019 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Statistical analyses of histological types of lung cancer in comparison with the control individuals indicated a significant difference between SULT1A1 Arg(213)His polymorphism and SCC (p = 0.027) and other types of cancer (p = 0.037), except SMCC (p = 0.854).
|
19350537 |
2009 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Statistically significant associations were observed between the SULT1A1 genotype (Arg213His) and age, obesity and certain neoplasias (mammary, pulmonary, esophageal and urothelial cancer).
|
14600802 |
2004 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan.
|
17619904 |
2008 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This review surveys the current knowledge of SULT genetic variability in relation to cancer risk and response to therapy, focusing primarily on SULT1A1.
|
24010997 |
2013 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The large number of environmental mutagens and carcinogens activated by sulfotransferases and the high frequency of the SULT1A1*1 allele in human populations warrants additional studies to address the role of SULT genes in human cancer.
|
11156380 |
2000 |